Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Benjamin Joseph Kopecky

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

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    K08HL159359     (KOPECKY, BENJAMIN J)Apr 1, 2022 - Mar 31, 2027
    NIH
    Dissecting the Role of Donor CCR2- Macrophages During Acute Cellular Rejection After Heart Transplantation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Van Ochten N, Leyba K, Kopecky BJ, Suckow E, Nathe K, Laing S, Lawley JS, Simpson L, Levine BD, Forbes LM, Cornwell Iii WK. The Impact of Moderate Altitude on Manifestations of Coronary Artery Disease. Gerontology. 2025 Apr 15; 1-13. PMID: 40359929.
      View in: PubMed
    2. Ambardekar AV, Kopecky BJ. Inflammation in Cardiogenic Liver Disease: The Guilty Perpetrator or an Innocent Bystander to Congestion? JACC Basic Transl Sci. 2025 Apr; 10(4):455-457. PMID: 40306853.
      View in: PubMed
    3. Gu S, Kopecky BJ, Pe?a B, Vagnozzi RJ, Lahm T. Sex-dependent Pathophysiology and Therapeutic Considerations in Right Heart Disease. Can J Cardiol. 2025 Jun; 41(6):1038-1053. PMID: 40054579.
      View in: PubMed
    4. Amrute JM, Luo X, Penna V, Yang S, Yamawaki T, Hayat S, Bredemeyer A, Jung IH, Kadyrov FF, Heo GS, Venkatesan R, Shi SY, Parvathaneni A, Koenig AL, Kuppe C, Baker C, Luehmann H, Jones C, Kopecky B, Zeng X, Bleckwehl T, Ma P, Lee P, Terada Y, Fu A, Furtado M, Kreisel D, Kovacs A, Stitziel NO, Jackson S, Li CM, Liu Y, Rosenthal NA, Kramann R, Ason B, Lavine KJ. Targeting immune-fibroblast cell communication in heart failure. Nature. 2024 Nov; 635(8038):423-433. PMID: 39443792.
      View in: PubMed
    5. Kadyrov FF, Koenig AL, Amrute JM, Dun H, Li W, Weinheimer CJ, Nigro JM, Kovacs A, Bredemeyer AL, Yang S, Das S, Penna VR, Parvathaneni A, Lai L, Hartmann N, Kopecky BJ, Kreisel D, Lavine KJ. Hypoxia sensing in resident cardiac macrophages regulates monocyte fate specification following ischemic heart injury. Nat Cardiovasc Res. 2024 Nov; 3(11):1337-1355. PMID: 39433910.
      View in: PubMed
    6. Dun H, Sticco-Ivins M, Terada Y, Berning A, Lavine KJ, Kreisel D, Kopecky BJ. Cervical heterotopic heart transplantation in mice using a novel suture technique. JHLT Open. 2025 Feb; 7:100164. PMID: 40144858.
      View in: PubMed
    7. Ambardekar AV, Kopecky BJ, Raymer DS. Finding an Unobstructed View Toward the Treatment of Nonobstructive Hypertrophic Cardiomyopathy: Lifting the Hunger Fog. J Am Coll Cardiol. 2024 May 28; 83(21):2049-2051. PMID: 38777508.
      View in: PubMed
    8. Zhang X, Heo GS, Li A, Lahad D, Detering L, Tao J, Gao X, Zhang X, Luehmann H, Sultan D, Lou L, Venkatesan R, Li R, Zheng J, Amrute J, Lin CY, Kopecky BJ, Gropler RJ, Bredemeyer A, Lavine K, Liu Y. Development of a CD163-Targeted PET Radiotracer That Images Resident Macrophages in Atherosclerosis. J Nucl Med. 2024 May 01; 65(5):775-780. PMID: 38548349.
      View in: PubMed
    9. Ambardekar AV, Kopecky BJ. The Farm to Table?HFpEF Kitchen: Selecting the Right Ingredients for the Discerning Palate. JACC Basic Transl Sci. 2024 Mar; 9(3):300-302. PMID: 38559628.
      View in: PubMed
    10. Owen MC, Kopecky BJ. Targeting Macrophages in Organ Transplantation: A Step Toward Personalized Medicine. Transplantation. 2024 10 01; 108(10):2045-2056. PMID: 38467591.
      View in: PubMed
    11. Kopecky BJ, Lavine KJ. Cardiac macrophage metabolism in health and disease. Trends Endocrinol Metab. 2024 03; 35(3):249-262. PMID: 37993313.
      View in: PubMed
    12. Bai YZ, Kopecky BJ, Lavine KJ, Kreisel D. Ferroptosis in the post-transplantation inflammatory response. Cell Immunol. 2023 Nov-Dec; 393-394:104774. PMID: 37839157.
      View in: PubMed
    13. Abboud R, Kim S, Staser K, Jayasinghe RG, Lim S, Amatya P, Frye CC, Kopecky B, Ritchey J, Gao F, Lavine K, Kreisel D, DiPersio JF, Choi J. Baricitinib with cyclosporine eliminates acute graft rejection in fully mismatched skin and heart transplant models. Front Immunol. 2023; 14:1264496. PMID: 37744381.
      View in: PubMed
    14. Tadepalli S, Clements DR, Saravanan S, Arroyo Hornero R, L?dtke A, Blackmore B, Paulo JA, Gottfried-Blackmore A, Seong D, Park S, Chan L, Kopecky BJ, Liu Z, Ginhoux F, Lavine KJ, Murphy JP, Mack M, Graves EE, Idoyaga J. Rapid recruitment and IFN-I-mediated activation of monocytes dictate focal radiotherapy efficacy. Sci Immunol. 2023 06 02; 8(84):eadd7446. PMID: 37294749.
      View in: PubMed
    15. Amrute JM, Lai L, Ma P, Koenig AL, Kamimoto K, Bredemeyer A, Shankar TS, Kuppe C, Kadyrov FF, Schulte LJ, Stoutenburg D, Kopecky BJ, Navankasattusas S, Visker J, Morris SA, Kramann R, Leuschner F, Mann DL, Drakos SG, Lavine KJ. Defining cardiac functional recovery in end-stage heart failure at single-cell resolution. Nat Cardiovasc Res. 2023 Apr; 2(4):399-416. PMID: 37583573.
      View in: PubMed
    16. Amrute JM, Luo X, Penna V, Bredemeyer A, Yamawaki T, Yang S, Kadyrov F, Heo GS, Shi SY, Lee P, Koenig AL, Kuppe C, Jones C, Kopecky B, Hayat S, Ma P, Terada Y, Fu A, Furtado M, Kreisel D, Stitziel NO, Li CM, Kramann R, Liu Y, Ason B, Lavine KJ. Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis. Res Sq. 2023 Jan 26. PMID: 36747878.
      View in: PubMed
    17. Borcherding N, Jia W, Giwa R, Field RL, Moley JR, Kopecky BJ, Chan MM, Yang BQ, Sabio JM, Walker EC, Osorio O, Bredemeyer AL, Pietka T, Alexander-Brett J, Morley SC, Artyomov MN, Abumrad NA, Schilling J, Lavine K, Crewe C, Brestoff JR. Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood. Cell Metab. 2022 10 04; 34(10):1499-1513.e8. PMID: 36070756.
      View in: PubMed
    18. Kopecky BJ, Dun H, Amrute JM, Lin CY, Bredemeyer AL, Terada Y, Bayguinov PO, Koenig AL, Frye CC, Fitzpatrick JAJ, Kreisel D, Lavine KJ. Donor Macrophages Modulate Rejection After Heart Transplantation. Circulation. 2022 08 23; 146(8):623-638. PMID: 35880523.
      View in: PubMed
    19. Moreno JD, Verma AK, Kopecky BJ, Dehner C, Kostelecky N, Vader JM, Lin CY, Schilling JD. Angiotensin II Type 1 Receptor Antibody-mediated Rejection Following Orthotopic Heart Transplant: A Single-center Experience. Transplantation. 2022 02 01; 106(2):373-380. PMID: 33988339.
      View in: PubMed
    20. Wong NR, Mohan J, Kopecky BJ, Guo S, Du L, Leid J, Feng G, Lokshina I, Dmytrenko O, Luehmann H, Bajpai G, Ewald L, Bell L, Patel N, Bredemeyer A, Weinheimer CJ, Nigro JM, Kovacs A, Morimoto S, Bayguinov PO, Fisher MR, Stump WT, Greenberg M, Fitzpatrick JAJ, Epelman S, Kreisel D, Sah R, Liu Y, Hu H, Lavine KJ. Resident cardiac macrophages mediate adaptive myocardial remodeling. Immunity. 2021 09 14; 54(9):2072-2088.e7. PMID: 34320366.
      View in: PubMed
    21. Kopecky BJ, Frye C, Terada Y, Balsara KR, Kreisel D, Lavine KJ. Role of donor macrophages after heart and lung transplantation. Am J Transplant. 2020 05; 20(5):1225-1235. PMID: 31850651.
      View in: PubMed
    22. Nichols DH, Bouma JE, Kopecky BJ, Jahan I, Beisel KW, He DZZ, Liu H, Fritzsch B. Interaction with ectopic cochlear crista sensory epithelium disrupts basal cochlear sensory epithelium development in Lmx1a mutant mice. Cell Tissue Res. 2020 Jun; 380(3):435-448. PMID: 31932950.
      View in: PubMed
    23. Heo GS, Kopecky B, Sultan D, Ou M, Feng G, Bajpai G, Zhang X, Luehmann H, Detering L, Su Y, Leuschner F, Combadi?re C, Kreisel D, Gropler RJ, Brody SL, Liu Y, Lavine KJ. Molecular Imaging Visualizes Recruitment of Inflammatory Monocytes and Macrophages to the Injured Heart. Circ Res. 2019 03 15; 124(6):881-890. PMID: 30661445.
      View in: PubMed
    24. Lavine KJ, Pinto AR, Epelman S, Kopecky BJ, Clemente-Casares X, Godwin J, Rosenthal N, Kovacic JC. The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4). J Am Coll Cardiol. 2018 10 30; 72(18):2213-2230. PMID: 30360829.
      View in: PubMed
    25. Tang J, Qian Y, Li H, Kopecky BJ, Ding D, Ou HC, DeCook R, Chen X, Sun Z, Kobel M, Bao J. Canertinib induces ototoxicity in three preclinical models. Hear Res. 2015 Oct; 328:59-66. PMID: 26163095.
      View in: PubMed
    26. Kopecky BJ, Liang R, Bao J. T-type calcium channel blockers as neuroprotective agents. Pflugers Arch. 2014 Apr; 466(4):757-65. PMID: 24563219.
      View in: PubMed
    27. Kopecky BJ, Jahan I, Fritzsch B. Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability. Dev Dyn. 2013 Feb; 242(2):132-47. PMID: 23193000.
      View in: PubMed
    28. Fritzsch B, Pan N, Jahan I, Duncan JS, Kopecky BJ, Elliott KL, Kersigo J, Yang T. Evolution and development of the tetrapod auditory system: an organ of Corti-centric perspective. Evol Dev. 2013 Jan; 15(1):63-79. PMID: 23331918.
      View in: PubMed
    29. Kopecky BJ, Duncan JS, Elliott KL, Fritzsch B. Three-dimensional reconstructions from optical sections of thick mouse inner ears using confocal microscopy. J Microsc. 2012 Dec; 248(3):292-8. PMID: 23140378.
      View in: PubMed
    30. Kopecky BJ, Decook R, Fritzsch B. N-Myc and L-Myc are essential for hair cell formation but not maintenance. Brain Res. 2012 Nov 12; 1484:1-14. PMID: 23022312.
      View in: PubMed
    31. Kopecky B, Fritzsch B. The myc road to hearing restoration. Cells. 2012 Sep 25; 1(4):667-98. PMID: 24710525.
      View in: PubMed
    32. Pan N, Kopecky B, Jahan I, Fritzsch B. Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation. Cell Tissue Res. 2012 Aug; 349(2):415-32. PMID: 22688958.
      View in: PubMed
    33. Kopecky B, Decook R, Fritzsch B. Mutational ataxia resulting from abnormal vestibular acquisition and processing is partially compensated for. Behav Neurosci. 2012 Apr; 126(2):301-13. PMID: 22309445.
      View in: PubMed
    34. Jahan I, Pan N, Kersigo J, Calisto LE, Morris KA, Kopecky B, Duncan JS, Beisel KW, Fritzsch B. Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival. PLoS One. 2012; 7(1):e30853. PMID: 22292060.
      View in: PubMed
    35. Kopecky B, Johnson S, Schmitz H, Santi P, Fritzsch B. Scanning thin-sheet laser imaging microscopy elucidates details on mouse ear development. Dev Dyn. 2012 Mar; 241(3):465-80. PMID: 22271591.
      View in: PubMed
    36. Pan N, Jahan I, Kersigo J, Duncan JS, Kopecky B, Fritzsch B. A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability. PLoS One. 2012; 7(1):e30358. PMID: 22279587.
      View in: PubMed
    37. Kopecky B, Fritzsch B. Regeneration of Hair Cells: Making Sense of All the Noise. Pharmaceuticals (Basel). 2011 Jun 01; 4(6):848-879. PMID: 21966254.
      View in: PubMed
    38. Kopecky B, Santi P, Johnson S, Schmitz H, Fritzsch B. Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear. Dev Dyn. 2011 Jun; 240(6):1373-90. PMID: 21448975.
      View in: PubMed
    39. Fritzsch B, Jahan I, Pan N, Kersigo J, Duncan J, Kopecky B. Dissecting the molecular basis of organ of Corti development: Where are we now? Hear Res. 2011 Jun; 276(1-2):16-26. PMID: 21256948.
      View in: PubMed
    40. Pan N, Jahan I, Kersigo J, Kopecky B, Santi P, Johnson S, Schmitz H, Fritzsch B. Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti. Hear Res. 2011 May; 275(1-2):66-80. PMID: 21146598.
      View in: PubMed
    41. Pauley S, Kopecky B, Beisel K, Soukup G, Fritzsch B. Stem cells and molecular strategies to restore hearing. Panminerva Med. 2008 Mar; 50(1):41-53. PMID: 18427387.
      View in: PubMed
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